Building in vitro models of the brain to understand the role of APOE in Alzheimer’s disease
Name
e202201542.full.pdf
Description
Published version
Size
2 MB
Format
Adobe PDF
Checksum (MD5)
e5c0915fb2e5e867a161354a34777859
Author(s)
Pinals, Rebecca L
Tsai, Li-Huei
Date Issued
2022
Journal
Life Science Alliance
Publisher
Life Science Alliance, LLC
Citation
Pinals, Rebecca L and Tsai, Li-Huei. 2022. "Building in vitro models of the brain to understand the role of APOE in Alzheimer’s disease." Life Science Alliance, 5 (11).
Version
Final published version
Abstract
Alzheimer’s disease (AD) is a devastating, complex, and incurable disease that represents an increasingly problematic global health issue. The etiology of sporadic AD that accounts for a vast majority of cases remains poorly understood, with no effective therapeutic interventions. Genetic studies have identified AD risk genes including the most prominent,APOE, of which the ɛ4 allele increases risk in a dose-dependent manner. A breakthrough discovery enabled the creation of human induced pluripotent stem cells (hiPSCs) that can be differentiated into various brain cell types, facilitating AD research in genetically human models. Herein, we provide a brief background on AD in the context ofAPOEsusceptibility and feature work employing hiPSC-derived brain cell and tissue models to interrogate the contribution ofAPOEin driving AD pathology. Such models have delivered crucial insights into cellular mechanisms and cell type–specific roles underlying the perturbed biological functions that trigger pathogenic cascades and propagate neurodegeneration. Collectively, hiPSC-based models are envisioned to be an impactful platform for uncovering fundamental AD understanding, with high translational value toward AD drug discovery and testing.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.26508/LSA.202201542
