Synthesis and optimization of synthetic intermediates to access C21-oxygenated aspidosperma alkaloids
Name
1199132256-MIT.pdf
Size
2.15 MB
Format
Adobe PDF
Checksum (MD5)
ae7728cb9ad98944abe35cab49c342fa
Author(s)
Avci, Nadide Hazal.
Advisor(s)
Mohammad Movassaghi.
Date Issued
2020
Publisher
Massachusetts Institute of Technology
Abstract
Synthesis and optimization of C21-oxygenated pentacyclic aspidosperma core is described. A highly effective enzymatic resolution of a non-[beta]-branched primary alcohol (E=22) allowed rapid preparation of both enantiomeric forms of a C21-oxygenated precursor for synthesis of aspidosperma alkaloids.
Description
Thesis: S.M., Massachusetts Institute of Technology, Department of Chemistry, 2020
Cataloged from PDF of thesis.
Includes bibliographical references.
Subjects
Chemistry.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
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