Fabrication of fillable microparticles and other complex 3D microstructures
Name
1138.full.pdf
Description
Published version
Size
847.78 KB
Format
Adobe PDF
Checksum (MD5)
be1ecc98821a9b35be2b709b3ffbd836
Author(s)
McHugh, Kevin J
Nguyen, Thanh D
Linehan, Allison R
Yang, David
Behrens, Adam M
Rose, Sviatlana
Tochka, Zachary L
Tzeng, Stephany Y
Norman, James J
Anselmo, Aaron C
Date Issued
2017
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Version
Final published version
Abstract
© 2017, American Association for the Advancement of Science. All rights reserved. Three-dimensional (3D) microstructures created by microfabrication and additive manufacturing have demonstrated value across a number of fields, ranging from biomedicine to microelectronics. However, the techniques used to create these devices each have their own characteristic set of advantages and limitations with regards to resolution, material compatibility, and geometrical constraints that determine the types of microstructures that can be formed. We describe a microfabrication method, termed StampEd Assembly of polymer Layers (SEAL), and create injectable pulsatile drug-delivery microparticles, pH sensors, and 3D microfluidic devices that we could not produce using traditional 3D printing. SEAL allows us to generate microstructures with complex geometry at high resolution, produce fully enclosed internal cavities containing a solid or liquid, and use potentially any thermoplastic material without processing additives.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1126/SCIENCE.AAF7447
