Estimation of nonlinear mechanical properties of atherosclerotic plaques
Name
66910312-MIT.pdf
Description
Full printable version
Size
7.45 MB
Format
Adobe PDF
Checksum (MD5)
a82813df111c7affc8707a02c5588c45
Author(s)
Zhu, Ting F. (Ting Fredrick)
Advisor(s)
Roger D. Kamm and Mohammad R. Kaazempur Mofrad.
Date Issued
2005
Publisher
Massachusetts Institute of Technology
Abstract
A numerical method has been developed to estimate the mechanical properties of atherosclerotic plaques by combining genetic algorithm with finite element methods. Plaque images derived from optical coherence tomography were employed to construct finite element models which were subsequently used in conjunction with a genetic algorithm to determine the parameters in a nonlinear constitutive model. A new multi-frame scheme is introduced to better perform the estimation on a nonlinear mechanical model and reduce the effects of noise. Results show while it is feasible to estimate the nonlinear mechanical properties of plaque, the accuracy can depend on various factors, especially the noise. KEY woRDS: FEM, atherosclerotic plaques, parameter estimation, Mooney-Rivlin model, optical coherence tomography, image noise.
Description
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2005.
Includes bibliographical references (leaves 57-59).
Subjects
Mechanical Engineering.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission.
Persistent DSpace Link
