The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway
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nihms891665.pdf
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808.3 KB
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Author(s)
Wolfson, Rachel Laura
Sabatini, David
Date Issued
August 2017
Journal
Cell Metabolism
Publisher
Elsevier BV
Citation
Wolfson, Rachel L., and David M. Sabatini. “The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway.” Cell Metabolism 26, 2 (August 2017): 301–309 © 2017 Elsevier Inc
Version
Author's final manuscript
Abstract
The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth that responds to a diverse set of environmental inputs, including amino acids. Over the past 10 years, a number of proteins have been identified that help transmit amino acid availability to mTORC1. However, amino acid sensors for this pathway have only recently been discovered. Here, we review these recent advances and highlight the variety of unexplored questions that emerge from the identification of these sensors. Wolfson and Sabatini describe recent advances in understanding how amino acids are sensed upstream of mTORC1, in particular detailing the discovery of the first amino acid sensors for the pathway. In addition, they analyze how components of the mTORC1 pathway, including the amino acid sensors, are conserved across evolution. Keywords: growth control; mTOR; mTORC1; amino acid sensing; nutrient sensing; amino acid sensors; Sestrins; Sestrin2; SLC38A9; CASTOR
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.CMET.2017.07.001
