Dynamic functional connectivity in the static connectome of Caenorhabditis elegans
Name
1-s2.0-S0959438821001549-main.pdf
Description
Published version
Size
1.45 MB
Format
Adobe PDF
Checksum (MD5)
9c4baa8f2014f990f18ca2eecb9691a0
Author(s)
Flavell, Steven W
Gordus, Andrew
Date Issued
2022
Journal
Current Opinion in Neurobiology
Publisher
Elsevier BV
Citation
Flavell, Steven W and Gordus, Andrew. 2022. "Dynamic functional connectivity in the static connectome of Caenorhabditis elegans." Current Opinion in Neurobiology, 73.
Version
Final published version
Abstract
A hallmark of adaptive behavior is the ability to flexibly respond to sensory cues. To understand how neural circuits implement this flexibility, it is critical to resolve how a static anatomical connectome can be modulated such that functional connectivity in the network can be dynamically regulated. Here, we review recent work in the roundworm Caenorhabditis elegans on this topic. EM studies have mapped anatomical connectomes of many C. elegans animals, highlighting the level of stereotypy in the anatomical network. Brain-wide calcium imaging and studies of specified neural circuits have uncovered striking flexibility in the functional coupling of neurons. The coupling between neurons is controlled by neuromodulators that act over long timescales. This gives rise to persistent behavioral states that animals switch between, allowing them to generate adaptive behavioral responses across environmental conditions. Thus, the dynamic coupling of neurons enables multiple behavioral states to be encoded in a physically stereotyped connectome.
MIT Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Creative Commons Attribution 4.0 International license
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.CONB.2021.12.002
