Three-dimensional optical coherence tomography of Barrett's esophagus glands beneath neosquamous epithelium following radiofrequency ablation
Name
Fujimoto-Three-dimensional optical.pdf
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Author(s)
Adler, David C.
Zhou, C.
Tsai, Tsung-Han
Lee, Hsiang-Chieh
Becker, L.
Schmitt, J. M.
Huang, Q.
Fujimoto, James G.
Mashimo, Hiroshi
Date Issued
September 2009
Journal
Endoscopy
Publisher
Thieme Publishing Group
Citation
Adler, D. et al. “Three-dimensional optical coherence tomography of Barrett’s esophagus and buried glands beneath neosquamous epithelium following radiofrequency ablation.” Endoscopy 41.09 (2009): 773-776.
Version
Author's final manuscript
Abstract
We report three-dimensional (3D) endoscopic microscopy findings in Barrett’s esophagus, using
an endoscopic optical coherence tomography (OCT) system in one patient before and in one
patient after radiofrequency ablation (RFA). Findings were compared with those in a normal
patient without Barrett’s esophagus. In the normal patient, findings were of regular flat squamous
mucosa with small subepithelial vessels and glands. In the Barrett’s esophagus patient, findings
were of large, densely packed glands with distortion of mucosal architecture. In the post-RFA
case, findings were of a small number of isolated glands buried beneath 300–500 μm of
neosquamous epithelium and lamina propria. Neosquamous epithelium is a marker of successful
ablative therapy, while buried glands may have potential for dysplastic progression and are
difficult to detect using conventional methods. These results indicate a potential role of 3D-OCT
endoscopic microscopy for follow-up, including subsurface assessment, of ablative treatments for
Barrett’s esophagus.
MIT Department
Massachusetts Institute of Technology. Department of Civil and Environmental Engineering
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Research Laboratory of Electronics
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DOI of Published Version
https://doi.org/10.1055/s-0029-1215045
