From Bench to the Clinic: The Path to Translation of Nanotechnology-Enabled mRNA SARS-CoV-2 Vaccines
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40820_2021_Article_771.pdf
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1.52 MB
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Checksum (MD5)
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Author(s)
Lopez-Cantu, Diana O.
Wang, Xichi
Carrasco-Magallanes, Hector
Afewerki, Samson
Zhang, Xingcai
Bonventre, Joseph V.
Ruiz-Esparza, Guillermo U.
Date Issued
January 3, 2022
Journal
Nano-Micro Letters
Publisher
Springer Singapore
Citation
Lopez-Cantu, D.O., Wang, X., Carrasco-Magallanes, H. et al. From Bench to the Clinic: The Path to Translation of Nanotechnology-Enabled mRNA SARS-CoV-2 Vaccines. Nano-Micro Lett. 14, 41 (2022)
Version
Final published version
Abstract
During the last decades, the use of nanotechnology in medicine has effectively been translated to the design of drug delivery systems, nanostructured tissues, diagnostic platforms, and novel nanomaterials against several human diseases and infectious pathogens. Nanotechnology-enabled vaccines have been positioned as solutions to mitigate the pandemic outbreak caused by the novel pathogen severe acute respiratory syndrome coronavirus 2. To fast-track the development of vaccines, unprecedented industrial and academic collaborations emerged around the world, resulting in the clinical translation of effective vaccines in less than one year. In this article, we provide an overview of the path to translation from the bench to the clinic of nanotechnology-enabled messenger ribonucleic acid vaccines and examine in detail the types of delivery systems used, their mechanisms of action, obtained results during each phase of their clinical development and their regulatory approval process. We also analyze how nanotechnology is impacting global health and economy during the COVID-19 pandemic and beyond.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. School of Engineering
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1007/s40820-021-00771-8
