HapTree-X: An Integrative Bayesian Framework for Haplotype Reconstruction from Transcriptome and Genome Sequencing Data
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nihms892746.pdf
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Author(s)
Berger, Emily R
Yorukoglu, Deniz
Berger Leighton, Bonnie
Date Issued
March 2015
Journal
Research in Computational Molecular Biology
Publisher
Springer Nature
Citation
Berger, Emily et al. “HapTree-X: An Integrative Bayesian Framework for Haplotype Reconstruction from Transcriptome and Genome Sequencing Data.” Research in Computational Molecular Biology (2015): 28–29 © 2015 Springer International Publishing Switzerland
Version
Author's final manuscript
Abstract
By running standard genotype calling tools, it is possible to accurately identify the number of wild type and mutant alleles for each single-nucleotide polymorphism (SNP) site. However, in the case of two heterozygous SNP sites, genotype calling tools cannot determine whether mutant alleles from different SNP loci are on the same chromosome or on different homologous chromosomes (i.e. compound heterozygote).
MIT Department
Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Massachusetts Institute of Technology. Department of Mathematics
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1007/978-3-319-16706-0_4
