Direct Cardiac Compression Devices to Augment Heart Biomechanics and Function
Name
annurev-bioeng-110220-025309.pdf
Size
4.3 MB
Format
Adobe PDF
Checksum (MD5)
1754e4d15c4719599c7b3b0577dc4c3e
Author(s)
Bonnemain, Jean
del Nido, Pedro J.
Roche, Ellen T.
Date Issued
June 6, 2022
Journal
Annual Review of Biomedical Engineering
Publisher
Annual Reviews
Citation
Bonnemain, Jean, del Nido, Pedro J. and Roche, Ellen T. 2022. "Direct Cardiac Compression Devices to Augment Heart Biomechanics and Function." Annual Review of Biomedical Engineering, 24 (1).
Version
Final published version
Abstract
The treatment of end-stage heart failure has evolved substantially with advances in medical treatment, cardiac transplantation, and mechanical circulatory support (MCS) devices such as left ventricular assist devices and total artificial hearts. However, current MCS devices are inherently blood contacting and can lead to potential complications including pump thrombosis, hemorrhage, stroke, and hemolysis. Attempts to address these issues and avoid blood contact led to the concept of compressing the failing heart from the epicardial surface and the design of direct cardiac compression (DCC) devices. We review the fundamental concepts related to DCC, present the foundational devices and recent devices in the research and commercialization stages, and discuss the milestones required for clinical translation and adoption of this technology.
Subjects
Biomedical Engineering
Medicine (miscellaneous)
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Massachusetts Institute of Technology. Department of Mechanical Engineering
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1146/annurev-bioeng-110220-025309
