Structure–function–property–design interplay in biopolymers: Spider silk
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nihms522123.pdf
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Author(s)
Tokareva, Olena
Jacobsen, Matthew
Wong, Joyce
Kaplan, David L.
Buehler, Markus J
Date Issued
August 2013
Journal
Acta Biomaterialia
Publisher
Elsevier BV
Citation
Tokareva, Olena et al. “Structure–function–property–design Interplay in Biopolymers: Spider Silk.” Acta Biomaterialia 10, 4 (April 2014): 1612–1626 © 2013 Acta Materialia Inc
Version
Author's final manuscript
Abstract
Spider silks have been a focus of research for almost two decades due to their outstanding mechanical and biophysical properties. Recent advances in genetic engineering have led to the synthesis of recombinant spider silks, thus helping to unravel a fundamental understanding of structure–function–property relationships. The relationships between molecular composition, secondary structures and mechanical properties found in different types of spider silks are described, along with a discussion of artificial spinning of these proteins and their bioapplications, including the role of silks in biomineralization and fabrication of biomaterials with controlled properties. Keywords: Spider silk; Proteins; Secondary structure; Self-assembly; Genetic engineering
MIT Department
Massachusetts Institute of Technology. Department of Civil and Environmental Engineering
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.ACTBIO.2013.08.020
