Advanced Oral Delivery Systems for Nutraceuticals
Name
Adv Healthcare Materials - 2025 - Yang - Advanced Oral Delivery Systems for Nutraceuticals.pdf
Description
Published version
Size
6.66 MB
Format
Adobe PDF
Checksum (MD5)
2304cbca536edbde2777bee853c97ce8
Author(s)
Yang, Xin
Zhang, Linzixuan
Zheng, Zhiling
Langer, Robert
Jaklenec, Ana
Date Issued
June 11, 2025
Journal
Advanced Healthcare Materials
Publisher
Wiley
Citation
X. Yang, L. Zhang, Z. Zheng, R. Langer, A. Jaklenec, Advanced Oral Delivery Systems for Nutraceuticals. Adv. Healthcare Mater. 2025, 2500271.
Version
Final published version
Abstract
Oral delivery is the most preferred route for nutraceuticals due to its convenience and high patient compliance. However, bioavailability is often compromised by poor solubility, instability, and first‐pass metabolism in the gastrointestinal tract. This review examines current and emerging oral delivery platforms designed to overcome these barriers and enhance nutraceutical efficacy. Traditional carriers—proteins, lipids, and carbohydrates—highlighting their delivery mechanisms and limitations, are first explored. Advancements in material science have led to novel platforms such as biodegradable polymers, metal–organic frameworks (MOFs), metal–polyphenol networks (MPNs), and 3D printing technologies. Biodegradable polymers improve stability and enable controlled release of bioactives. MOFs offer high surface area and tunable porosity for encapsulating and protecting sensitive compounds. MPNs provide biocompatible, stimuli‐responsive systems for targeted nutrient delivery. Meanwhile, 3D printing facilitates the fabrication of personalized delivery systems with precise control over composition and release kinetics, especially when integrated with artificial intelligence (AI) for precision nutrition. By comparing traditional and next‐generation strategies, this review outlines key design principles for optimizing oral delivery systems. The transformative potential of these innovations is underscored to improve the bioavailability and therapeutic outcomes of nutraceuticals, ultimately advancing personalized and targeted nutrition solutions.
MIT Department
Koch Institute for Integrative Cancer Research at MIT
Massachusetts Institute of Technology. Department of Chemical Engineering
Terms of Use
Creative Commons Attribution
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1002/adhm.202500271
