Nuclear Factor I/B is an Oncogene in Small Cell Lung Cancer
Name
Dooley_Manuscript.pdf
Description
main article
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1.93 MB
Format
Adobe PDF
Checksum (MD5)
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Author(s)
Dooley, Alison L.
Winslow, Monte Meier
Chiang, Derek Y.
Banerji, Shantanu
Stransky, Nicolas
Dayton, Talya Lucia
Snyder, Eric
Senna, Stephanie
Whittaker, Charles A.
Bronson, Roderick T.
Date Issued
October 2011
Journal
Genes and Development
Publisher
Cold Spring Harbor Laboratory Press in association with The Genetics Society
Citation
Dooley, A. L. et al. “Nuclear factor I/B is an oncogene in small cell lung cancer.” Genes & Development 25 (2011): 1470-1475.
Version
Author's final manuscript
Abstract
Small cell lung cancer (SCLC) is an aggressive cancer often diagnosed after it has metastasized. Despite the need to better understand this disease, SCLC remains poorly characterized at the molecular and genomic levels. Using a genetically engineered mouse model of SCLC driven by conditional deletion of Trp53 and Rb1 in the lung, we identified several frequent, high-magnitude focal DNA copy number alterations in SCLC. We uncovered amplification of a novel, oncogenic transcription factor, Nuclear factor I/B (Nfib), in the mouse SCLC model and in human SCLC. Functional studies indicate that NFIB regulates cell viability and proliferation during transformation.
MIT Department
Broad Institute of MIT and Harvard
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1101/gad.2046711
