CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity
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Regev_CD5L AIM.pdf
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Author(s)
Wang, Chao
Yosef, Nir
Gaublomme, Jellert
Wu, Chuan
Lee, Youjin
Clish, Clary B.
Kaminski, Jim
Xiao, Sheng
Zu Horste, Gerd Meyer
Pawlak, Mathias
Date Issued
November 2015
Journal
Cell
Publisher
Elsevier
Citation
Wang, Chao et al. “CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity.” Cell 163.6 (2015): 1413–1427.
Version
Author's final manuscript
Abstract
Th17 cells play a critical role in host defense against extracellular pathogens and tissue homeostasis, but can induce autoimmunity. The mechanisms implicated in balancing ‘pathogenic’ and ‘non-pathogenic’ Th17 cell states remain largely unknown. We used single-cell RNA-seq to
identify CD5L/AIM as a regulator expressed in ‘non-pathogenic’ but not in ‘pathogenic’ Th17 cells. Although CD5L does not affect Th17 differentiation, it is a functional switch that regulates the pathogenicity of Th17 cells. Loss of CD5L converts ‘non-pathogenic’ Th17 cells into
‘pathogenic’ cells that induce autoimmunity. CD5L mediates this effect by modulating the intracellular lipidome, altering fatty acid composition, and restricting cholesterol biosynthesis, and thus ligand availability for Rorγt, the master transcription factor of Th17 cells. Our study identifies
CD5L as a critical regulator of the Th17 cell functional state and highlights the importance of lipid metabolism in balancing immune protection and disease induced by T cells.
MIT Department
Massachusetts Institute of Technology. Department of Biology
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Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.cell.2015.10.068
