Morphology-Dependent Luminescence in Complex Liquid Colloids
Name
doi-10.1021 jacs.8b13215.pdf
Description
Accepted version
Size
525.14 KB
Format
Adobe PDF
Checksum (MD5)
ed9a087cb78c00ec65d74fff1a4d8a36
Author(s)
Lin, Che-Jen
Zeininger, Lukas
Savagatrup, Suchol
Swager, Timothy M
Date Issued
February 2019
Journal
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Citation
Lin, Che-Jen et al. "Morphology-Dependent Luminescence in Complex Liquid Colloids." Journal of the American Chemical Society 141, 9 (February 2019): 3802–3806 © 2019 American Chemical Society
Version
Author's final manuscript
Abstract
Complex liquid colloids hold great promise as transducers in sensing applications as a result of their tunable morphology and intrinsic optical properties. Herein, we introduce meta-amino substituted green fluorescence protein chromophore (GFPc) surfactants that localize at the organic-water interface of complex multiphase liquid colloids. The meta-amino GFPc exhibits hydrogen-bonding (HB) mediated fluorescence quenching, and are nearly nonemissive in the presence of protic solvents. We demonstrate morphology-dependent fluorescence of complex liquid colloids and investigate the interplay between GFPc surfactants and other simple surfactants. This environmentally responsive surfactant allows us to observe morphological changes of complex emulsions in randomized orientations. We demonstrate utility with an enzyme activity based fluorescence "turn-ON" scheme. The latter employs an oligopeptide-linked GFPc that functions as both a surfactant and trypsin target. The cleavage of hydrophilic peptide results in a morphology change and ultimately a fluorescence turn-on. Fluorescent complex colloids represent a new approach for biosensing in liquid environments.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies
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DOI of Published Version
https://doi.org/10.1021/jacs.8b13215
