Hidden Randomness between Fitness Landscapes Limits Reverse Evolution
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Tan-2011-Hidden Randomness be.pdf
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Author(s)
Tan, Longzhi
Serene, Stephen R.
Chao, Hui Xiao
Gore, Jeff
Date Issued
May 2011
Journal
Physical review letters
Publisher
American Physical Society
Citation
Tan, Longzhi et al. “Hidden Randomness Between Fitness Landscapes Limits Reverse Evolution.” Physical Review Letters 106.19 (2011) : n. pag. © 2011 American Physical Society
Version
Final published version
Abstract
In biological evolution, adaptations to one environment can in some cases reverse adaptations to another environment. To study this “reverse evolution” on a genotypic level, we measured the fitness of E. coli strains with each possible combination of five mutations in an antibiotic-resistance gene in two distinct antibiotic environments. While adaptations to one environment generally lower fitness in the other, we find that reverse evolution is rarely possible and falls as the complexity of adaptations increases, suggesting a probabilistic, molecular form of Dollo’s law.
MIT Department
Massachusetts Institute of Technology. Department of Physics
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DOI of Published Version
https://doi.org/10.1103/PhysRevLett.106.198102
