Biological and computational tools for systems biology : application to Fas signaling pathways in T cells
Name
57204222-MIT.pdf
Description
Full printable version
Size
6.73 MB
Format
Adobe PDF
Checksum (MD5)
5c8bb64ae83c1e1a957d1d9f7ee6a17d
Author(s)
Yokoo, Rayka, 1980-
Advisor(s)
Luk Van Parijs.
Date Issued
2004
Publisher
Massachusetts Institute of Technology
Abstract
With the development of new experimental technologies, biologists have begun to take a more global view into cell function, approaching its study in a more systematic manner than previously possible. This thesis develops three new tools to perform systems biology studies of cell death in T cells: A modeling program, JDesigner; high throughput T cell apoptosis assays; and an RNAi sequence prediction program. These tools are then applied to a biological and mathematical analysis of Fas signaling pathways in T cells.
Description
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2004.
Includes bibliographical references (leaves 43-44).
Subjects
Electrical Engineering and Computer Science.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Terms of Use
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