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Widespread and Highly Correlated Somato-dendritic Activity in Cortical Layer 5 Neurons
Name
nihms-1529577.pdf
Description
Accepted version
Size
1.4 MB
Format
Adobe PDF
Checksum (MD5)
207cf333b419b55ded2f74a4d72b8ee5
Author(s)
Beaulieu-Laroche, Lou
Toloza, Enrique HS
Brown, Norma J
Harnett, Mark T
Date Issued
2019
Journal
Neuron
Publisher
Elsevier BV
Citation
Beaulieu-Laroche, Lou, Toloza, Enrique HS, Brown, Norma J and Harnett, Mark T. 2019. "Widespread and Highly Correlated Somato-dendritic Activity in Cortical Layer 5 Neurons." Neuron, 103 (2).
Version
Author's final manuscript
Abstract
© 2019 Elsevier Inc. Dendritic integration can expand the information-processing capabilities of neurons. However, the recruitment of active dendritic processing in vivo and its relationship to somatic activity remain poorly understood. Here, we use two-photon GCaMP6f imaging to simultaneously monitor dendritic and somatic compartments in the awake primary visual cortex. Activity in layer 5 pyramidal neuron somata and distal apical trunk dendrites shows surprisingly high functional correlation. This strong coupling persists across neural activity levels and is unchanged by visual stimuli and locomotion. Ex vivo combined somato-dendritic patch-clamp and GCaMP6f recordings indicate that dendritic signals specifically reflect local electrogenesis triggered by dendritic inputs or high-frequency bursts of somatic action potentials. In contrast to the view that dendrites are only sparsely recruited under highly specific conditions in vivo, our results provide evidence that active dendritic integration is a widespread and intrinsic feature of cortical computation. Beaulieu-Laroche et al. perform near-simultaneous calcium imaging of somatic and dendritic activity to reveal that active dendritic integration is an integral feature of information processing in cortical pyramidal neurons.
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
10.1016/J.NEURON.2019.05.014
