Discriminating noise from chaos in heart rate variability : application to prognosis in heart failure
Name
213391321-MIT.pdf
Description
Full printable version
Size
9.87 MB
Format
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Checksum (MD5)
26ef3caf141356830c3e0fc6a0e628c4
Author(s)
Arzeno, Natalia M. (Natalia María Arzeno Soltero)
Advisor(s)
Chi-Sang Poon.
Date Issued
2007
Publisher
Massachusetts Institute of Technology
Abstract
This thesis examines two challenging problems in chaos analysis: distinguishing deterministic chaos and stochastic (noise-induced) chaos, and applying chaotic heart rate variability (HRV) analysis to the prognosis of mortality in congestive heart failure (CHF). Distinguishing noise from chaos poses a major challenge in nonlinear dynamics theory since the addition of dynamic noise can make a non-chaotic nonlinear system exhibit stochastic chaos, a concept which is not well-defined and is the center of heated debate in chaos theory. A novel method for detecting dynamic noise in chaotic series is proposed in Part I of this thesis. In Part II, we show that linear and nonlinear analyses of HRV yield independent predictors of mortality. Specifically, sudden death is best predicted by frequency analysis whereas nonlinear and chaos indices are more selective for progressive pump failure death. These findings suggest a novel noninvasive probe for the clinical management of CHF patients.
Description
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2007.
Includes bibliographical references (p. 103-109).
Subjects
Electrical Engineering and Computer Science.
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
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