Early Detection of the Aflatoxin B₁ Mutational Fingerprint: A Diagnostic Tool for Liver Cancer
Name
Early detection of the aflatoxin B1 mutational fingerprint A diagnostic tool for liver cancer.pdf
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2 MB
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Author(s)
Fedeles, Bogdan I
Chawanthayatham, Supawadee
Croy, Robert G
Wogan, Gerald N
Essigmann, John M
Date Issued
July 2017
Journal
Molecular & Cellular Oncology
Publisher
Informa UK Limited
Citation
Fedeles, Bogdan I. et al. “Early Detection of the Aflatoxin B₁ Mutational Fingerprint: A Diagnostic Tool for Liver Cancer.” Molecular & Cellular Oncology 4, 4 (May 2017): e1329693 © 2017 The Author(s)
Version
Final published version
Abstract
Using duplex-consensus sequencing technology, we recently identified the characteristic high-resolution mutational spectrum of the liver carcinogen aflatoxin B₁ in a mouse model, many months before aflatoxin-induced tumors are detectable. The diagnostic power of this spectrum is then demonstrated by accurately identifying, among the sequenced human liver tumors, the subset of cancers associated with aflatoxin B₁ exposure. Keywords: Duplex sequencing; HCC; hepatocellular carcinoma; mutagenesis; mutational signature; mycotoxins
MIT Department
Massachusetts Institute of Technology. Center for Environmental Health Sciences
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1080/23723556.2017.1329693
