Mitigation of partial volume effects in susceptibility-based oxygenation measurements by joint utilization of magnitude and phase (JUMP): Partial Volume Effects in Susceptibility-Based Oxygenation Measurements
Name
nihms767109.pdf
Description
Accepted version
Size
2.34 MB
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Checksum (MD5)
04a9e3187c9df13c1945191e32ec7cdf
Author(s)
McDaniel, Patrick Christopher
Bilgic, Berkin
Fan, Audrey
Stout, Jeffrey
Adalsteinsson, Elfar
Date Issued
April 2017
Journal
Magnetic resonance in medicine
Publisher
Wiley-Blackwell
Citation
McDaniel, Patrick, Berkin Bilgic, Audrey Fan, Jeffrey Stout, and Elfar Adalsteinsson, "Mitigation of partial volume effects in susceptibility-based oxygenation measurements by joint utilization of magnitude and phase (JUMP): Partial Volume Effects in Susceptibility-Based Oxygenation Measurements." Magnetic resonance in medicine 77, 4 (April 2017): p. 1713-27 doi 10.1002/MRM.262Stout27 ©2017 Author(s)
Version
Author's final manuscript
Abstract
Purpose: Susceptibility-based blood oxygenation measurements in small vessels of the brain derive from gradient echo (GRE) phase and can provide localized assessment of brain function and pathology. However, when vessel diameter becomes smaller than the acquisition voxel size, partial volume effects compromise these measurements. The purpose of this study was to develop a technique to improve the reliability of vessel oxygenation estimates in the presence of partial volume effects. Methods: Intravoxel susceptibility variations are present when a vessel and parenchyma experience partial volume effects, modifying the voxel's GRE phase signal and attenuating the GRE magnitude signal. Using joint utilization of magnitude and phase (JUMP), both vessel susceptibility and voxel partial volume fraction can be estimated, providing measurements of venous oxygen saturation (Yv) in straight, nearly vertical vessels that have improved robustness to partial volume effects. Results: JUMP was demonstrated by estimating vessel Yv in numerical and in vivo experiments. Deviations from ground truth of Yv measurements in vessels tilted up to 30° from B0 were reduced by over 50% when using JUMP compared with phase-only techniques. Conclusion: JUMP exploits both magnitude and phase data in GRE imaging to mitigate partial volume effects in estimation of vessel oxygenation. ©2017
MIT Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Harvard University--MIT Division of Health Sciences and Technology
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DOI of Published Version
https://doi.org/10.1002/MRM.262Stout27
