Engram Cell Excitability State Determines the Efficacy of Memory Retrieval
Name
Pignatelli et al. 2018 Neuron.pdf
Description
Accepted version
Size
5.81 MB
Format
Adobe PDF
Checksum (MD5)
5fe16a706d82a59da7cb5f11eb0c7c1a
Author(s)
Pignatelli di Spinazzola, Michele
Rivera, Tomás
Roy, Dheeraj
Lovett, Chanel W. L.
Smith, Lillian
Muralidhar, Shruti
Tonegawa, Susumu
Date Issued
January 2019
Journal
Neuron
Publisher
Elsevier BV
Citation
Pignatelli, Michele et al. "Engram Cell Excitability State Determines the Efficacy of Memory Retrieval." Neuron 101, 2 (January 2019): P274-284.e5 © 2018 Elsevier Inc
Version
Author's final manuscript
Abstract
Animals need to optimize the efficacy of memory retrieval to adapt to environmental circumstances for survival. The recent development of memory engram labeling technology allows a precise investigation of the processes associated with the recall of a specific memory. Here, we show that engram cell excitability is transiently increased following memory reactivation. This short-term increase of engram excitability enhances the subsequent retrieval of specific memory content in response to cues and is manifest in the animal's ability to recognize contexts more precisely and more effectively. These results reveal a hitherto unknown transient enhancement of context recognition based on the plasticity of engram cell excitability. They also suggest that recall of a contextual memory is influenced by previous but recent activation of the same engram. The state of excitability of engram cells mediates differential behavioral outcomes upon memory retrieval and may be crucial for survival by promoting adaptive behavior.
MIT Department
RIKEN-MIT Center for Neural Circuit Genetics
Massachusetts Institute of Technology. Department of Biology
Picower Institute for Learning and Memory
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.neuron.2018.11.029
