Designing, building, and testing the spin, strip, and stomp mechanism for pharmaceutical tableting
Name
1004237382-MIT.pdf
Description
Full printable version
Size
40.31 MB
Format
Adobe PDF
Checksum (MD5)
43c8a6aa7e0e0db6d88a7b88b6288189
Author(s)
Labib, Shahd Hassan
Advisor(s)
Alexander Slocum.
Date Issued
2017
Publisher
Massachusetts Institute of Technology
Abstract
Nanofiber fabrication of pharmaceutical pills creates significant advantages over conventional techniques such as shorter pill dissolution times, airborne drug particulate matter elimination, and shorter liquid drying time, among many others. Therefore, the Novartis MIT Center for Continuous Manufacturing is prioritizing development of electrospinning techniques for producing nanofibrous pills. However, electrospinning pills still has a very low production rate compared to that of the current pharmaceutical techniques. Motivated by the need for an efficient and effective elecrospinning technique, we developed the "Spin, Strip, and Stomp Mechanism." This technique has successfully made pills of the required quality, designed with the goal of reducing the gap between the low production rates of nanofibrous pills and the high rates of the current pill making techniques.
Description
Thesis: S.M., Massachusetts Institute of Technology, Department of Mechanical Engineering, June 2017.
"May 2017." Cataloged from PDF version of thesis.
Includes bibliographical references (pages 226-229).
Subjects
Mechanical Engineering.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
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