Physical magnification of objects
Name
c8mh00931g.pdf
Size
1.58 MB
Format
Adobe PDF
Checksum (MD5)
1612dd3f1d0c1264a7a009abd6624a8c
Author(s)
Boyden, Edward
Date Issued
October 2018
Journal
Materials Horizons
Publisher
Royal Society of Chemistry (RSC)
Citation
Boyden, Edward S. “Physical Magnification of Objects.” Materials Horizons (October 2018) © Royal Society of Chemistry
Version
Final published version
Abstract
For hundreds of years, scientists have aimed photons, electrons, and X-rays at objects in order to obtain magnified images of them, revealing their micro- and nanoscale architecture, and revolutionizing every branch of the sciences. Recently a new modality of magnification was discovered – physical magnification of objects. For objects with certain properties, such as biological specimens, one can synthesize throughout them a dense, even network of swellable polymer, so that further chemical processing steps will isotropically expand the polymer, and thus the object, manyfold in physical dimension. We here explore the principles governing this new modality of magnification, such as the ability to use inexpensive, ubiquitous imaging hardware to perform high-resolution imaging of objects, and the ability to decrowd molecules within an object for detailed in situ chemical analysis.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Massachusetts Institute of Technology. Media Laboratory
Koch Institute for Integrative Cancer Research at MIT
Terms of Use
Creative Commons Attribution-NonCommercial 3.0 Unported
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1039/C8MH00931G
