Three-dimensional chromatin organization in brain function and dysfunction
Name
1-s2.0-S0959438821000532-main.pdf
Description
Published version
Size
1.02 MB
Format
Unknown
Checksum (MD5)
6276dd6ebb6f03c2191f060721dc0fe8
Author(s)
Dileep, Vishnu
Tsai, Li-Huei
Date Issued
2021
Journal
Current Opinion in Neurobiology
Publisher
Elsevier BV
Citation
Dileep, Vishnu and Tsai, Li-Huei. 2021. "Three-dimensional chromatin organization in brain function and dysfunction." Current Opinion in Neurobiology, 69.
Version
Final published version
Abstract
The three-dimensional (3D) organization of chromatin within the nucleus is now recognized as a bona fide epigenetic property influencing genome function, replication, and maintenance. In the recent years, several studies have revealed how 3D chromatin organization is associated with brain function and its emerging role in disorders of the brain. 3D chromatin organization plays a crucial role in the development of different cell types of the nervous system and some neuronal cell types have adapted unique modifications to this organization that deviates from all other cell types. In post-mitotic neurons, dynamic changes in chromatin interactions in response to neuronal activity underlie learning and memory formation. Finally, new evidence directly links 3D chromatin organization to several disorders of the brain. These recent findings position 3D chromatin organization as a fundamental regulatory mechanism poised to reveal the etiology of brain function and dysfunctions.
MIT Department
Picower Institute for Learning and Memory
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/J.CONB.2021.04.006
