Brains, Genes, and Primates
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Zhang_Brains, genes.pdf
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547.16 KB
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Author(s)
Belmonte, Juan Carlos Izpisua
Callaway, Edward M.
Caddick, Sarah J.
Churchland, Patricia
Feng, Guoping
Homanics, Gregg E.
Lee, Kuo-Fen
Leopold, David A.
Miller, Cory T.
Mitchell, Jude F.
Date Issued
May 2015
Journal
Neuron
Publisher
Elsevier
Citation
Belmonte, Juan Carlos Izpisua, Edward M. Callaway, Sarah J. Caddick, Patricia Churchland, Guoping Feng, Gregg E. Homanics, Kuo-Fen Lee, et al. “Brains, Genes, and Primates.” Neuron 86, no. 3 (May 2015): 617–31.
Version
Author's final manuscript
Abstract
One of the great strengths of the mouse model is the wide array of genetic tools that have been developed. Striking examples include methods for directed modification of the genome, and for regulated expression or inactivation of genes. Within neuroscience, it is now routine to express reporter genes, neuronal activity indicators, and opsins in specific neuronal types in the mouse. However, there are considerable anatomical, physiological, cognitive, and behavioral differences between the mouse and the human that, in some areas of inquiry, limit the degree to which insights derived from the mouse can be applied to understanding human neurobiology. Several recent advances have now brought into reach the goal of applying these tools to understanding the primate brain. Here we describe these advances, consider their potential to advance our understanding of the human brain and brain disorders, discuss bioethical considerations, and describe what will be needed to move forward.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
McGovern Institute for Brain Research at MIT
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Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.neuron.2015.03.021
