Interplay of active processes modulates tension and drives phase transition in self-renewing, motor-driven cytoskeletal networks
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Mak-2016-Interplay of Active.pdf
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Author(s)
Mak, Michael
Zaman, Muhammad H.
Kim, Taeyoon
Kamm, Roger Dale
Date Issued
January 2016
Journal
Nature Communications
Publisher
Nature Publishing Group
Citation
Mak, Michael, Muhammad H. Zaman, Roger D. Kamm, and Taeyoon Kim. “Interplay of Active Processes Modulates Tension and Drives Phase Transition in Self-Renewing, Motor-Driven Cytoskeletal Networks.” Nat Comms 7 (January 8, 2016): 10323.
Version
Final published version
Abstract
The actin cytoskeleton—a complex, nonequilibrium network consisting of filaments, actin-crosslinking proteins (ACPs) and motors—confers cell structure and functionality, from migration to morphogenesis. While the core components are recognized, much less is understood about the behaviour of the integrated, disordered and internally active system with interdependent mechano-chemical component properties. Here we use a Brownian dynamics model that incorporates key and realistic features—specifically actin turnover, ACP (un)binding and motor walking—to reveal the nature and underlying regulatory mechanisms of overarching cytoskeletal states. We generate multi-dimensional maps that show the ratio in activity of these microscopic elements determines diverse global stress profiles and the induction of nonequilibrium morphological phase transition from homogeneous to aggregated networks. In particular, actin turnover dynamics plays a prominent role in tuning stress levels and stabilizing homogeneous morphologies in crosslinked, motor-driven networks. The consequence is versatile functionality, from dynamic steady-state prestress to large, pulsed constrictions.
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Mechanical Engineering
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DOI of Published Version
https://doi.org/10.1038/ncomms10323
