An implantable soft robotic ventilator augments inspiration in a pig model of respiratory insufficiency
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s41551-022-00971-6.pdf
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Author(s)
Hu, Lucy
Bonnemain, Jean
Saeed, Mossab Y.
Singh, Manisha
Quevedo Moreno, Diego
Vasilyev, Nikolay V.
Roche, Ellen T.
Date Issued
December 12, 2022
Journal
Nature Biomedical Engineering
Publisher
Springer Science and Business Media LLC
Citation
Hu, L., Bonnemain, J., Saeed, M.Y. et al. An implantable soft robotic ventilator augments inspiration in a pig model of respiratory insufficiency. Nat. Biomed. Eng 7, 110–123 (2023).
Version
Final published version
Abstract
Severe diaphragm dysfunction can lead to respiratory failure and to the need for permanent mechanical ventilation. Yet permanent tethering to a mechanical ventilator through the mouth or via tracheostomy can hinder a patient’s speech, swallowing ability and mobility. Here we show, in a porcine model of varied respiratory insufficiency, that a contractile soft robotic actuator implanted above the diaphragm augments its motion during inspiration. Synchronized actuation of the diaphragm-assist implant with the native respiratory effort increased tidal volumes and maintained ventilation flow rates within the normal range. Robotic implants that intervene at the diaphragm rather than at the upper airway and that augment physiological metrics of ventilation may restore respiratory performance without sacrificing quality of life.
Subjects
Computer Science Applications
Biomedical Engineering
Medicine (miscellaneous)
Bioengineering
Biotechnology
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Massachusetts Institute of Technology. Department of Mechanical Engineering
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1038/s41551-022-00971-6
