Engram cells retain memory under retrograde amnesia
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Author(s)
Ryan, Tomas John
Roy, Dheeraj
Pignatelli di Spinazzola, Michele
Arons, Autumn
Tonegawa, Susumu
Date Issued
May 2015
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Ryan, T. J. et al. “Engram Cells Retain Memory under Retrograde Amnesia.” Science 348.6238 (2015): 1007–1013.
Version
Author's final manuscript
Abstract
Memory consolidation is the process by which a newly formed and unstable memory transforms into a stable long-term memory. It is unknown whether the process of memory consolidation occurs exclusively through the stabilization of memory engrams. By using learning-dependent cell labeling, we identified an increase of synaptic strength and dendritic spine density specifically in consolidated memory engram cells. Although these properties are lacking in engram cells under protein synthesis inhibitor–induced amnesia, direct optogenetic activation of these cells results in memory retrieval, and this correlates with retained engram cell–specific connectivity. We propose that a specific pattern of connectivity of engram cells may be crucial for memory information storage and that strengthened synapses in these cells critically contribute to the memory retrieval process.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Picower Institute for Learning and Memory
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1126/science.aaa5542
