Acetate metabolism in cancer cells
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s40170-014-0027-y.pdf
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176.76 KB
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Adobe PDF
Checksum (MD5)
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Author(s)
Hosios, Aaron M
Vander Heiden, Matthew G.
Date Issued
2014
Journal
Cancer & Metabolism
Publisher
BioMed Central Ltd
Citation
Hosios, Aaron M. and Matthew G. Vander Heiden. "Acetate metabolism in cancer cells." Cancer & Metabolism 2014, 2:27.
Version
Final published version
Abstract
Macromolecule biosynthesis is required to duplicate cell components and support proliferation. Studies examining the nutrients used by cancer cells have focused on the contribution of glucose and glutamine carbon for biosynthesis, but the importance of other metabolic fuels is becoming apparent. Labeling of two-carbon units in newly synthesized lipids has been used to infer the nutrients that contribute to the acetyl-CoA pools in cells. Glucose- and glutamine-derived carbon are known to contribute extensively to de novo lipid biosynthesis, and in this issue Kamphorst et al. find that extracellular acetate can also contribute substantially to this process [1].
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution
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DOI of Published Version
https://doi.org/10.1186/s40170-014-0027-y
