Palladium-Catalyzed Amination of Unprotected Halo-7- azaindoles
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Buchwald_Palladium Catalyzed.pdf
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Author(s)
Henderson, Jaclyn L.
McDermott, Sarah M.
Buchwald, Stephen Leffler
Date Issued
September 2010
Journal
Organic Letters
Publisher
American Chemical Society (ACS)
Citation
Henderson, Jaclyn L., Sarah M. McDermott, and Stephen L. Buchwald. “Palladium-Catalyzed Amination of Unprotected Halo-7-azaindoles.” Organic Letters 12.20 (2010): 4438–4441.
Version
Author's final manuscript
Abstract
Simple and efficient procedures for the Pd-catalyzed cross-coupling of primary and secondary amines with halo-7-azaindoles(pyrrolo[2,3-b]pyridine) are presented. Previously, no general method was available to ensure the highly selective reaction of the heteroaryl halide in the presence of the unprotected azaindole N-H. Using palladium precatalysts recently reported by our group, such reactions are easily accomplished under mild conditions that can be applied to cross-coupling reactions with a wide array of aliphatic and aromatic amines.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Massachusetts Institute of Technology. Department of Humanities. History Section
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DOI of Published Version
https://doi.org/10.1021/ol101928m
