The matrix reloaded: the evolution of regenerative hydrogels
Name
Jabbari-2016-The matrix reloaded_.pdf
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1.39 MB
Format
Adobe PDF
Checksum (MD5)
1772e36d88a3859e8fd56daadb8377ee
Author(s)
Jabbari, Esmaiel
Leijten, Jeroen
Xu, Qiaobing
Khademhosseini, Alireza
Date Issued
May 2016
Journal
Materials Today
Publisher
Elsevier
Citation
Jabbari, Esmaiel, Jeroen Leijten, Qiaobing Xu, and Ali Khademhosseini. “The Matrix Reloaded: The Evolution of Regenerative Hydrogels.” Materials Today 19, no. 4 (May 2016): 190–196.
Version
Final published version
Abstract
Cell-laden hydrogels can regenerate lost, damaged or malfunctioning tissues. Clinical success of such hydrogels is strongly dependent on the ability to tune their chemical, physico-mechanical, and biological properties to a specific application. In particular, mimicking the intricate arrangement of cell-interactive ligands of natural tissues is crucial to proper tissue function. Natural extracellular matrix elements represent a unique source for generating such interactions. A plethora of extracellular matrix-based approaches have been explored to augment the regenerative potential of hydrogels. These efforts include the development of matrix-like hydrogels, hydrogels containing matrix-like molecules, hydrogels containing decellularized matrix, hydrogels derived from decellularized matrix, and decellularized tissues as reimplantable matrix hydrogels. Here we review the evolution, strengths and weaknesses of these developments from the perspective of creating tissue regenerating hydrogels.
MIT Department
Institute for Medical Engineering and Science
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Biological Engineering
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.mattod.2015.10.005
