Can the meniscus affect the nature of a chondrocyte?
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Grodzinsky-2009-Can the meniscus affect.pdf
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38.54 KB
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Author(s)
Vanderploeg, Eric J.
Grodzinsky, Alan J.
Date Issued
May 2009
Journal
Osteoarthritis and Cartilage
Publisher
Elsevier Ltd.
Citation
Vanderploeg, E.J., and A.J. Grodzinsky. “Can the meniscus affect the nature of a chondrocyte?” Osteoarthritis and Cartilage 17 (2009): 969-970. Web. 26 Oct. 2011. © 2011 Elsevier Ltd.
Version
Author's final manuscript
Abstract
It is well understood that proper joint kinematics and loading are important factors in maintaining the health of the articular cartilage of the knee. This state of normal, physiologic loading facilitates a balance between anabolic and catabolic processes resulting in low level, homeostatic cartilage matrix turn-over and remodeling. In this way articular cartilage can function throughout an entire lifetime without loss of its load bearing or lubricating characteristics. However, situations that dramatically alter knee joint biomechanics, such as chronic disuse or overuse[superscript 1-4], anterior cruciate ligament (ACL) injury[superscript 5,6], or damage to the fibrocartilaginous menisci[superscript 7-11], can result in progressive cartilage degradation and strongly correlate with the onset of osteoarthritis (OA).
MIT Department
Massachusetts Institute of Technology. Center for Biomedical Engineering
Massachusetts Institute of Technology. Department of Biological Engineering
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Massachusetts Institute of Technology. Department of Mechanical Engineering
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Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1016/j.joca.2009.05.007
