Total synthesis of himastatin
Name
total-synthesis-of-himastatin.pdf
Description
Submitted version
Size
9.24 MB
Format
Adobe PDF
Checksum (MD5)
3c688c51af836cc2e0c9493b3f32e856
Author(s)
D’Angelo, Kyan A
Schissel, Carly K
Pentelute, Bradley L
Movassaghi, Mohammad
Date Issued
February 25, 2022
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Citation
D’Angelo, Kyan A, Schissel, Carly K, Pentelute, Bradley L and Movassaghi, Mohammad. 2022. "Total synthesis of himastatin." Science, 375 (6583).
Version
Original manuscript
Abstract
The natural product himastatin has an unusual homodimeric structure that presents a substantial synthetic challenge. We report the concise total synthesis of himastatin from readily accessible precursors, incorporating a final-stage dimerization strategy that was inspired by a detailed consideration of the compound’s biogenesis. Combining this approach with a modular synthesis enabled expedient access to more than a dozen designed derivatives of himastatin, including synthetic probes that provide insight into its antibiotic activity.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1126/science.abm6509
