BE.440 Analysis of Biological Networks, Fall 2004
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BE-440Fall-2004/OcwWeb/Biological-Engineering-Division/BE-440Fall-2004/CourseHome/index.htm
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Author(s) •
Essigmann, John
Sasisekharan, Ram
Alternative Title
Analysis of Biological Networks
Date Issued
December 2004
Abstract
This class analyzes complex biological processes from the molecular, cellular, extracellular, and organ levels of hierarchy. Emphasis is placed on the basic biochemical and biophysical principles that govern these processes. Examples of processes to be studied include chemotaxis, the fixation of nitrogen into organic biological molecules, growth factor and hormone mediated signaling cascades, and signaling cascades leading to cell death in response to DNA damage. In each case, the availability of a resource, or the presence of a stimulus, results in some biochemical pathways being turned on while others are turned off. The course examines the dynamic aspects of these processes and details how biochemical mechanistic themes impinge on molecular/cellular/tissue/organ-level functions. Chemical and quantitative views of the interplay of multiple pathways as biological networks are emphasized. Student work will culminate in the preparation of a unique grant application in an area of biological networks.
Subjects
systems
networks
biochemistry
biology
chemistry
chemotaxis
lactation
interferon
response
DNA
replication
translation
transcription
RNA
IFN
signals
signaling
cellular
receptor
MIT Department
Massachusetts Institute of Technology. Department of Biological Engineering
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