Massive normalization of olfactory bulb output in mice with a 'monoclonal nose'
Name
Roland-2016-Massive normalizatio.pdf
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6.04 MB
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Checksum (MD5)
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Author(s)
Roland, Benjamin
Jordan, Rebecca
Sosulski, Dara L.
Diodato, Assunta
Fukunaga, Izumi
Wickersham, Ian R.
Franks, Kevin M.
Schaefer, Andreas T.
Fleischmann, Alexander
Date Issued
May 2016
Journal
eLife
Publisher
eLife Sciences Publications, Ltd.
Citation
Roland, Benjamin, Rebecca Jordan, Dara L Sosulski, Assunta Diodato, Izumi Fukunaga, Ian Wickersham, Kevin M Franks, Andreas T Schaefer, and Alexander Fleischmann. “Massive Normalization of Olfactory Bulb Output in Mice with a ‘Monoclonal Nose.’” eLife 5 (May 13, 2016), pp.1-25.
Version
Final published version
Abstract
Perturbations in neural circuits can provide mechanistic understanding of the neural correlates of behavior. In M71 transgenic mice with a “monoclonal nose”, glomerular input patterns in the olfactory bulb are massively perturbed and olfactory behaviors are altered. To gain insights into how olfactory circuits can process such degraded inputs we characterized odor-evoked responses of olfactory bulb mitral cells and interneurons. Surprisingly, calcium imaging experiments reveal that mitral cell responses in M71 transgenic mice are largely normal, highlighting a remarkable capacity of olfactory circuits to normalize sensory input. In vivo whole cell recordings suggest that feedforward inhibition from olfactory bulb periglomerular cells can mediate this signal normalization. Together, our results identify inhibitory circuits in the olfactory bulb as a mechanistic basis for many of the behavioral phenotypes of mice with a “monoclonal nose” and highlight how substantially degraded odor input can be transformed to yield meaningful olfactory bulb output.
MIT Department
McGovern Institute for Brain Research at MIT
Wickersham Laboratory (Massachusetts Institute of Technology)
Terms of Use
Creative Commons Attribution 4.0 International License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.7554/eLife.16335
