Transcriptional insights into the CD8[superscript +] T cell response to infection and memory T cell formation
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Regev_Transcriptional insights.pdf
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Author(s)
Regev, Aviv
Best, J. Adam
Blair, David A.
Knell, Jamie
Yang, Edward
Mayya, Viveka
Doedens, Andrew
Dustin, Michael L.
Goldrath, Ananda W.
Date Issued
February 2013
Journal
Nature Immunology
Publisher
Nature Publishing Group
Citation
Best, J Adam, David A Blair, Jamie Knell, Edward Yang, Viveka Mayya, Andrew Doedens, Michael L Dustin, et al. “Transcriptional Insights into the CD8+ T Cell Response to Infection and Memory T Cell Formation.” Nature Immunology 14, no. 4 (February 10, 2013): 404–412.
Version
Author's final manuscript
Abstract
After infection, many factors coordinate the population expansion and differentiation of CD8[superscript +] effector and memory T cells. Using data of unparalleled breadth from the Immunological Genome Project, we analyzed the CD8[superscript +] T cell transcriptome throughout infection to establish gene-expression signatures and identify putative transcriptional regulators. Notably, we found that the expression of key gene signatures can be used to predict the memory-precursor potential of CD8[superscript +] effector cells. Long-lived memory CD8[superscript +] cells ultimately expressed a small subset of genes shared by natural killer T and γδ T cells. Although distinct inflammatory milieu and T cell precursor frequencies influenced the differentiation of CD8[superscript +] effector and memory populations, core transcriptional signatures were regulated similarly, whether polyclonal or transgenic, and whether responding to bacterial or viral model pathogens. Our results provide insights into the transcriptional regulation that influence memory formation and CD8[superscript +] T cell immunity.
MIT Department
Massachusetts Institute of Technology. Department of Biology
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1038/ni.2536
