Bridging the "Valley of Death" in stratified medicine : commercializing molecular diagnostics in oncology
Name
809045007-MIT.pdf
Description
Full printable version
Size
11.56 MB
Format
Adobe PDF
Checksum (MD5)
3dce8449e8a410ea4c34d7b473003820
Author(s)
Copp, Joshua
Advisor(s)
Ernst R. Berndt.
Alternative Title
Commercializing molecular diagnostics in oncology
Date Issued
2012
Publisher
Massachusetts Institute of Technology
Abstract
Historically, the development of molecular companion diagnostics in oncology has underwhelmed the expectation of the medical field since the successful mapping of the human genome a decade ago. There have been several highly successful developments (Her2-neu, Genomic Health, etc.), but not the widespread revolution in clinical practice expected at the turn of the century. The primary goal of this document is to investigate the economics driving molecular diagnostics and its relationship with strategic decisions in developing a diagnostic technology. The document begins with a broad analysis of the funding environment for molecular and esoteric diagnostics in oncology. Following a discussion of funding sources and current trends, the second section reviews the nature of the projects that funding supports. This is accomplished through a set of detailed case studies of Genomic Health and Immunicon to compare and contrast the strategic decisions that led to value creation events for both companies. Finally, the third section abstracts away from specific cases to develop a strategic analytic framework for evaluating the potential risk-adjusted NPV for a new diagnostic technology. Sensitivity analyses are conducted in addition to a discussion of current events that may change the structure of the underlying decision tree. The conclusion revisits the topics discussed in the first three sections, connecting the implications of funding on different strategic decisions and chances of success. Areas for further investigation both for inputs to the current model proposed, as well as for more refined versions of the development model are discussed.
Description
Thesis (M.B.A.)--Massachusetts Institute of Technology, Sloan School of Management, 2012.
Cataloged from PDF version of thesis.
Includes bibliographical references (p. 69-81).
Subjects
Sloan School of Management.
MIT Department
Sloan School of Management
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