The zero-sum game of pathway optimization: Emerging paradigms for tuning gene expression
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Solmon_BTJ_revision_submitted.pdf
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2.73 MB
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5f1557d5821fd1ecd7bd894dba3fe412
Author(s)
Solomon, Kevin
Prather, Kristala L. Jones
Date Issued
September 2011
Journal
Biotechnology Journal
Publisher
John Wiley & Sons, Inc.
Citation
Solomon, Kevin V., and Kristala L. J. Prather. The Zero-sum Game of Pathway Optimization: Emerging Paradigms for Tuning Gene Expression. Biotechnology Journal 6, no. 9 (September 21, 2011): 1064-1070.
Version
Author's final manuscript
Abstract
With increasing price volatility and growing awareness of the lack of sustainability of traditional chemical synthesis, microbial chemical production has been tapped as a promising renewable alternative for the generation of diverse, stereospecific compounds. Nonetheless, many attempts to generate them are not yet economically viable. Due to the zero-sum nature of microbial resources, traditional strategies of pathway optimization are attaining minimal returns. This result is in part a consequence of the gross changes in host physiology resulting from such efforts and underscores the need for more precise and subtle forms of gene modulation. In this review, we describe alternative strategies and emerging paradigms to address this problem and highlight potential solutions from the emerging field of synthetic biology.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
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Creative Commons Attribution-Noncommercial-Share Alike 3.0
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DOI of Published Version
https://doi.org/10.1002/biot.201100086
