Nanoparticles for Targeted Drug Delivery
Name
MEBCS014.pdf
Size
11.9 KB
Format
Adobe PDF
Checksum (MD5)
3c1180ba4f5230a136c3896f48bfce2f
Author(s)
Chow, Gan-Moog
Date Issued
January 2004
Series/Report no.
Molecular Engineering of Biological and Chemical Systems (MEBCS);
Abstract
Nanoparticles were synthesized and modified for target drug delivery. The research involved the aqueous synthesis of near infrared (NIR) sensitive Au-Au2S nanoparticles. An anti-cancer drug (cis-platin) was subsequently adsorbed onto the Au-Au2S nanoparticle surface via the 11-mercaptoundecanoic acid layers. The results showed that the degree of adsorption of cis-platin onto Au-Au2S nanoparticles was controlled by the pH value of solution, and the rate of drug release was sensitive to NIR irradiation. The results of the synthesis, drug-release properties and nanoparticle-cell interactions will be discussed.
Subjects
nanoparticles
targeted drug delivery
near infrared sensitive Au-Au<sub>2</sub>S nanoparticles
anti-cancer drugs
NIR irradiation
adsorption of cis-platin
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