7.342 The X in Sex: A Genetic, Medical, and Evolutionary View of the X Chromosome, Fall 2009
Author(s)
Mueller, Jacob
Alternative Title
The X in Sex: A Genetic, Medical, and Evolutionary View of the X Chromosome
Date Issued
December 2009
Abstract
This course will explore a diverse collection of striking biological phenomena associated with the X chromosome. We will examine the genetic basis and significance of several X-linked mutations. We will also discuss why men are more likely than women to display X-linked traits. We will look at the different mechanisms by which X chromosome gene expression is equalized in mammals, flies, and worms and how these mechanisms can yield unusual phenotypes. Throughout our discussions of the X chromosome we will use both recent and classic primary research papers to learn about this chromosome's fascinating biology. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanced Undergraduate Seminars are postdoctoral scientists with a strong interest in teaching.
Subjects
X chromosome
genetics
flies
mammals
worms
sex reversal
dosage compensation
X-inactivation
hybrid
Haldane's rule
drosophila
gene
dna
dosage
pedigree
genetic map
Thomas Hunt Morgan
Calvin Bridges
Alfred Sturtevant
evolution
MIT Department
Massachusetts Institute of Technology. Department of Biology
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