Low‐coherent optical diffraction tomography by angle‐scanning illumination
Name
1807.05677.pdf
Description
Accepted version
Size
455.91 KB
Format
Adobe PDF
Checksum (MD5)
cffb06b97b6523598c7d4a08475ecee5
Author(s)
Lee, KyeoReh
Shin, Seungwoo
Yaqoob, Zahid
So, Peter TC
Park, YongKeun
Date Issued
2019
Journal
Journal of Biophotonics
Publisher
Wiley
Version
Author's final manuscript
Abstract
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Temporally low-coherent optical diffraction tomography (ODT) is proposed and demonstrated based on angle-scanning Mach-Zehnder interferometry. Using a digital micromirror device based on diffractive tilting, the full-field interference of incoherent light is successfully maintained during every angle-scanning sequences. Further, current ODT reconstruction principles for temporally incoherent illuminations are thoroughly reviewed and developed. Several limitations of incoherent illumination are also discussed, such as the nondispersive assumption, optical sectioning capacity and illumination angle limitation. Using the proposed setup and reconstruction algorithms, low-coherent ODT imaging of plastic microspheres, human red blood cells and rat pheochromocytoma cells is experimentally demonstrated.
MIT Department
Massachusetts Institute of Technology. Laser Biomedical Research Center
Massachusetts Institute of Technology. Spectroscopy Laboratory
Massachusetts Institute of Technology. Department of Mechanical Engineering
Massachusetts Institute of Technology. Department of Biological Engineering
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1002/JBIO.201800289
