Concise Palladium-Catalyzed Synthesis of Dibenzodiazepines and Structural Analogs
Name
Buchwald_Concise palladium.pdf
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1.52 MB
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Author(s)
Tsvelikhovsky, Dmitry
Buchwald, Stephen Leffler
Alternative Title
Concise Palladium-Catalyzed Synthesis of Dibenzodiazepines and Structural Analogues
Date Issued
August 2011
Journal
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Citation
Tsvelikhovsky, Dmitry, and Stephen L. Buchwald. “Concise Palladium-Catalyzed Synthesis of Dibenzodiazepines and Structural Analogues.” Journal of the American Chemical Society 133, no. 36 (September 14, 2011): 14228-14231.
Version
Author's final manuscript
Abstract
A general and highly efficient protocol for the synthesis of dibenzodiazepines and their structural analogues is reported. In the presence of catalytic quantities of palladium, readily accessible precursors are cross-coupled with ammonia and then spontaneously undergo an intramolecular condensation to form the corresponding dibenzodiazepines in one step. This new strategy is applicable to the construction of a wide variety of dibenzooxazepines and other structurally related heterocycles.
MIT Department
Massachusetts Institute of Technology. Department of Chemistry
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/ja206229y
