Wireless Magnetothermal Deep Brain Stimulation
Name
Anikeeva_Wireless magnetothermal.pdf
Size
843 KB
Format
Adobe PDF
Checksum (MD5)
33dcc84eb814e0d45cf6478a291b01ba
Author(s)
Chen, Ritchie
Romero Uribe, Gabriela
Christiansen, Michael Gary
Mohr, Alan C.
Anikeeva, Polina Olegovna
Date Issued
March 2015
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Citation
Chen, Ritchie, Gabriela Romero, Michael G. Christiansen, Alan Mohr, and Polina Anikeeva. Wireless magnetothermal deep brain stimulation. Science 347.6229 (March 27, 2015), pp. 1477-1480.
Version
Author's final manuscript
Abstract
Wireless deep brain stimulation of well-defined neuronal populations could facilitate the study of intact brain circuits and the treatment of neurological disorders. Here we demonstrate minimally-invasive and remote neural excitation through the activation of the heat-sensitive capsaicin receptor TRPV1 by magnetic nanoparticles. When exposed to alternating magnetic fields, the nanoparticles dissipate heat generated by hysteresis, triggering widespread and reversible firing of TRPV1+ neurons. Wireless magnetothermal stimulation in the ventral tegmental area of mice evoked excitation in subpopulations of neurons in the targeted brain region and in structures receiving excitatory projections. The nanoparticles persisted in the brain for over a month, allowing for chronic stimulation without the need for implants and connectors.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Materials Science and Engineering
Massachusetts Institute of Technology. Research Laboratory of Electronics
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1126/science.1261821
