Bioelectrochemical platforms to study and detect emerging pathogens
Name
43577_2021_172_ReferencePDF.pdf
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1.19 MB
Format
Adobe PDF
Checksum (MD5)
4f90e622ee058c5b63c5e561617864e8
Author(s)
Machado, Mary C.
Zamani, Marjon
Daniel, Susan
Furst, Ariel L.
Date Issued
August 31, 2021
Publisher
Springer International Publishing
Citation
Machado, Mary C., Zamani, Marjon, Daniel, Susan and Furst, Ariel L. 2021. "Bioelectrochemical platforms to study and detect emerging pathogens."
Version
Author's final manuscript
Abstract
Abstract
The ongoing SARS-CoV-2 pandemic has emphasized the importance of technologies to rapidly detect emerging pathogens and understand their interactions with hosts. Platforms based on the combination of biological recognition and electrochemical signal transduction, generally termed bioelectrochemical platforms, offer unique opportunities to both sense and study pathogens. Improved bio-based materials have enabled enhanced control over the biotic–abiotic interface in these systems. These improvements have generated platforms with the capability to elucidate biological function rather than simply detect targets. This advantage is a key feature of recent bioelectrochemical platforms applied to infectious disease. Here, we describe developments in materials for bioelectrochemical platforms to study and detect emerging pathogens. The incorporation of host membrane material into electrochemical devices has provided unparalleled insights into the interaction between viruses and host cells, and new capture methods have enabled the specific detection of bacterial pathogens, such as those that cause secondary infections with SARS-CoV-2. As these devices continue to improve through the merging of hi-tech materials and biomaterials, the scalability and commercial viability of these devices will similarly improve.
Graphic Abstract
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Terms of Use
Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1557/s43577-021-00172-7
