Structural insights into LINC complexes
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Schwartz_Structural insights.pdf
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Author(s)
Kutay, Ulrike
Schwartz, Thomas
Sosa, Brian A.
Date Issued
April 2013
Journal
Current Opinion in Structural Biology
Publisher
Elsevier
Citation
Sosa, Brian A, Ulrike Kutay, and Thomas U Schwartz. “Structural Insights into LINC Complexes.” Current Opinion in Structural Biology 23, no. 2 (April 2013): 285–291.
Version
Author's final manuscript
Abstract
Communication between nucleus and cytoplasm extends past molecular exchange and critically includes mechanical wiring. Cytoskeleton and nucleoskeleton are connected via molecular tethers that span the nuclear envelope. Sad1, UNC84 (SUN)-domain proteins spanning the inner nuclear membrane and Klarsicht, ANC-1 and SYNE/Nesprin-1 and -2 Homology (KASH)-peptide bearing proteins residing in the outer nuclear membrane directly bind and constitute the core of the LInkers of Nucleoskeleton and Cytoskeleton (LINC) complex. These connections appear critical for a growing number of biological processes and aberrations are implicated in a host of diverse diseases, including muscular dystrophies, cardiomyopathies, and premature aging. We discuss recent developments in this vibrant research area, particularly in context of first structural insights into LINC complexes reported in the past year.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.sbi.2013.03.005
