Probing nanoantenna-directed photothermal destruction of tumors using noninvasive laser irradiation
Name
Bhatia_Probing nanoantenna.pdf
Size
367.72 KB
Format
Adobe PDF
Checksum (MD5)
844b43e9e90540c1a06bad7e5b0a0c16
Author(s)
DasGupta, Debabrata
von Maltzahn, Geoffrey
Ghosh, Soham
Bhatia, Sangeeta N.
Das, Sarit K.
Chakraborty, Suman
Date Issued
December 2009
Journal
Applied Physical Letters
Publisher
American Institute of Physics
Citation
DasGupta, Debabrata et al. “Probing nanoantenna-directed photothermal destruction of tumors using noninvasive laser irradiation.” Applied Physics Letters 95.23 (2009): 233701-3. © 2009 American Institute of Physics.
Version
Final published version
Abstract
Plasmonic nanomaterials have tremendous potential to improve the tumor specificity of traditional cancer ablation practices, yet little effort has been directed toward quantitatively understanding their photothermal energy conversion in tumor tissues. In the present work, we develop a predictive model for plasmonic nanomaterial assisted tumor destruction under extracorporeal laser irradiation. Instead of appealing to heuristically based laser intensification models with tunable, tissue absorption and scattering coefficients, we consider fundamental characteristics of optoelectrothermal energy conversion and heat dissipation for plasmonic nanomaterials within living tumor tissues to construct a simulation tool that accurately reproduces our experimental findings, including aspects of delayed time-temperature characteristics. We believe the comprehensive modeling strategy outlined here provides a groundwork for the development of anticipatory therapeutic planning tools with individually tailored treatment plans, resulting in an ultimate benefit to ailing cancer patients.
MIT Department
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Terms of Use
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1063/1.3271522
