In Vivo Compatibility of Graphene Oxide with Differing Oxidation States
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Anderson_In vivo compatibility.pdf
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Author(s)
Sydlik, Stefanie Arlene
Jhunjhunwala, Siddharth
Webber, Matthew
Anderson, Daniel Griffith
Langer, Robert S
Date Issued
April 2015
Journal
ACS Nano
Publisher
American Chemical Society (ACS)
Citation
Sydlik, Stefanie A. et al. “In Vivo Compatibility of Graphene Oxide with Differing Oxidation States.” ACS Nano 9.4 (2015): 3866–3874.
Version
Author's final manuscript
Abstract
Graphene oxide (GO) is suggested to have great potential as a component of biomedical devices. Although this nanomaterial has been demonstrated to be cytocompatible in vitro, its compatibility in vivo in tissue sites relevant for biomedical device application is yet to be fully understood. Here, we evaluate the compatibility of GO with two different oxidation levels following implantation in subcutaneous and intraperitoneal tissue sites, which are of broad relevance for application to medical devices. We demonstrate GO to be moderately compatible in vivo in both tissue sites, with the inflammatory reaction in response to implantation consistent with a typical foreign body reaction. A reduction in the degree of GO oxidation results in faster immune cell infiltration, uptake, and clearance following both subcutaneous and peritoneal implantation. Future work toward surface modification or coating strategies could be useful to reduce the inflammatory response and improve compatibility of GO as a component of medical devices.
MIT Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Harvard University--MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology. Department of Chemical Engineering
Koch Institute for Integrative Cancer Research at MIT
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1021/acsnano.5b01290
