Functional implications of inhibitory synapse placement on signal processing in pyramidal neuron dendrites
Name
nihms939245.pdf
Description
Accepted version
Size
618.06 KB
Format
Adobe PDF
Checksum (MD5)
85d553795c3c2c8d4c6eb6d8fd16f774
Author(s)
Boivin, Josiah R.
Nedivi, Elly
Date Issued
February 2018
Journal
Current Opinion in Neurobiology
Publisher
Elsevier BV
Citation
Boivin, Josiah R. and Elly Nedivi. "Functional implications of inhibitory synapse placement on signal processing in pyramidal neuron dendrites." Current Opinion in Neurobiology 51 (August 2018): 16-22 © 2018 Elsevier
Version
Author's final manuscript
Abstract
A rich literature describes inhibitory innervation of pyramidal neurons in terms of the distinct inhibitory cell types that target the soma, axon initial segment, or dendritic arbor. Less attention has been devoted to how localization of inhibition to specific parts of the pyramidal dendritic arbor influences dendritic signal detection and integration. The effect of inhibitory inputs can vary based on their placement on dendritic spines versus shaft, their distance from the soma, and the branch order of the dendrite they inhabit. Inhibitory synapses are also structurally dynamic, and the implications of these dynamics depend on their dendritic location. Here we consider the heterogeneous roles of inhibitory synapses as defined by their strategic placement on the pyramidal cell dendritic arbor.
MIT Department
Picower Institute for Learning and Memory
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Massachusetts Institute of Technology. Department of Biology
Terms of Use
Creative Commons Attribution-NonCommercial-NoDerivs License
Persistent DSpace Link
DOI of Published Version
https://doi.org/10.1016/j.conb.2018.01.013
