Computational Investigation of Dynamic Properties of Actin Networks with Crosslinking Proteins
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Author(s)
Kim, Taeyoon
Hwang, Wonmuk
Kamm, Roger Dale
Date Issued
February 2010
Journal
Proceedings of the ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology (NEMB2010)
Publisher
American Society of Mechanical Engineers
Citation
Kim, Taeyoon, Wonmuk Hwang, and Roger D. Kamm. "Computational Investigation of Dynamic Properties of Actin Networks With Crosslinking Proteins." Proceedings of the ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology (NEMB2010), February 7–10, 2010, Houston, Texas, USA Sponsor: ASME Nanotechnology Council. ©2010 ASME.
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Final published version
Abstract
Due to the increasing recognition of the role that force plays in biological processes, a new field, mechanobiology, has recently emerged. One aspect of this is the need to gain a physical understanding of the viscoelastic properties of the cytoskeleton. Numerous studies, both in living cells and in reconstituted actin gels, have been conducted, but important questions still remain. Of these an important issue revolves around the role played by actin crosslinking proteins (ACPs), and whether they undergo unfolding or unbinding under stress. This issue is complicated by the fact that single molecule studies show that both events occur within a similar range of forces, on the order of 20–100 pN.
MIT Department
Massachusetts Institute of Technology. Department of Mechanical Engineering
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Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
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DOI of Published Version
https://doi.org/10.1115/NEMB2010-13156
